Advancing firstinclass G Protein-Coupled Receptor (GPCR)-targeted drugs to address serious, unserved medical needs across a broad range of neuro-inflammatory indications.

Mas-Related G Protein-Coupled Receptors or Mrgprs are chemosensory receptors that belong to the class A GPCRs family. They are believed to act as surveillance detectors for offensive stimuli from both the external and internal environments.

Each of the eight known human Mrgprs displays a unique tissue distribution. As such, each Mrgprs has the potential for being a target for intervention thus addressing a range of therapeutic areas.

Escient will initially target serious unserved medical needs focusing on the neuro-immuno inflammatory axis. It is now clear that neural activation of the immune system plays a role in numerous clinical conditions. At Escient we believe that targeting this important disease axis will produce a number of novel and life-changing medicines.